protein C

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Protein C is a vitamin K-dependent protease which complements the anticoagulant activity of antithrombin III by inactivating factors VIII and V. It also stimulates fibrinolysis. It is regulated by protein S on the surface of endothelial cells and requires calcium as a co-factor.

Homozygotes lacking protein C die in the early neonatal period, if not before, from overwhelming coagulation.

Last reviewed 01/2018