This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Pathology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Steatosis is usual, most frequently macrovesicular, and there may be cirrhosis. The hepatitis is characterised by:

  • ballooning and necrosis of hepatocytes:
    • mainly in zone 3, near the central veins
    • hepatocellular damage results in retention of secretory proteins and water, causing the cells to swell

  • Mallory bodies:
    • due to disorganisation of the cytoskeleton by alcohol or acetaldehyde
    • also seen in Wilson's disease and primary biliary cirrhosis

  • inflammatory infiltrate:
    • polymorphonuclear leukocytic infiltrate

  • pericellular and perivenular fibrosis:
    • attributed to the transformation of Ito cells to fibroblasts
    • fibrous septae may eventually form between contiguous perivenular areas and between hepatic veins and portal tracts

Related pages

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page