This site is intended for healthcare professionals
Login | Register (NOW FREE)

Medical search

sarcoidosis

FREE subscriptions for doctors and students... click here
You have 3 open access pages.

Sarcoidosis is a multisystemic inflammatory disorder of unknown etiology characterized by the accumilation of non-caseating epithelioid granulomas in involved organs (1).

  • the disease may occur at any age but is usually present in adults under the age of 50 years with a peak in incidence between the 20 and 39 years of age (2)
  • any organ system can be involved but lung involvement dominate in most of patients (2)    
  • diagnosis is made when clinicoradiologic findings are supported with histological analysis of tissue samples for evidence of noncaseating epitheliod cell granulomas (3).

The course of the disease is variable:

  • acute sarcoidosis
    • usually follows a benign course
    • more commonly seen in young white adults
    • characterised by diffuse usually bilateral ankle swelling with or without erythema nodosum and bilateral hilar lymph node involvement
  • chronic and recurrent sarcoidosis,
    • affects elderly patients, more commonly the Afro-Caribbean population and may have multisystem involvement
    • lung infiltration may progress to pulmonary fibrosis
    • may be resistant to conventional treatment (4)

The clinical manifestations of sarcoidosis are diverse (4):

  • the accumulation of T-lymphocytes, mononuclear phagocytic cells and non-caseating granulomas occurs in involved organs. These granulomas may resolve spontaneously or lead to secondary fibrosis and permanent organ damage
  • sarcoidosis involves the lungs in over 90% of cases and commonly the lymphoreticular system, skin, eyes, muscles and joints. Less commonly other organs, including the heart, kidneys, brain and peripheral nervous system, may be clinically affected

Reference:

Links:

The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions LtdĀ®. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions LtdĀ® receives funding from advertising but maintains editorial independence. GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service. If you do not want to receive cookies please do not use GPnotebook.