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Whipple's disease

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Whipple's disease is a rare systemic disease caused by the bacillus Tropheryma whippelii.

The disease usually has an insidious course with consequent delay in diagnosis. Initial features are non-specific with arthralgia, fever, malaise, cough and pleuritic chest pain. Characteristic small bowel dysfunction may occur between 1 and 10 years after onset. Histology of a small bowel biopsy is usually diagnostic.

Treatment consists of longterm broad spectrum antibiotics.


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