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haemorrhagic disease of the newborn and antiepileptic drugs

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  • mortality associated with neonatal bleeding from vitamin K1 deficiency is over 30%

  • exposure to enzyme-inducing drugs increases the risk of haemorrhagic disease of the newborn. This includes exposure to antiepileptic drugs such as carbamazepine, phenytoin and phenobarbitone (1)

  • it is recommended that infants with prenatal exposure to antiepileptic drugs should receive 1mg vitamin K intramuscularly at birth (1)


  • (1) Prescriber (2001), 12 (18), 30-36.


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