Urticaria and itching are relatively common effects of transfusion due to antibodies in recipient plasma against donor plasma proteins.
Less commonly, allergy may be associated with antibodies against IgA; IgA deficiency occurs in less than 1 in 10,000 of the population.
Overall, some allergic reaction develops in 1-2% of transfusions.
Treatment is usually with chlorphenamine (piriton) which also, may be given before transfusion if repeated especially if allergic reactions have been noted in the past.
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