diseases treated

Last reviewed 01/2018

Non-malignant disease:

  • aplastic anaemia - results in disease free survival in more than 50% of patients
  • thalassaemia
  • sickle cell anaemia
  • immunodeficiency diseases - including severe combined immunodeficiency disease, Wiskott-Aldrich syndrome
  • Gaucher's disease

Malignant disease:

  • acute myeloid leukaemia - high dose chemotherapy or radiotherapy and BMT is potentially curative; allogeneic is generally preferred
  • acute lymphoblastic leukaemia - as standard intensive chemotherapy is so effective, BMT is reserved for special situations such as Philadelphia positive ALL. Allogeneic is usually preferred, as it is associated with a lower rate of relapse
  • chronic myeloid leukaemia - with the introduction of imatinib, allogeneic stem cell transplantation is no longer considered as the first line treatment method in patients with chronic phase of CML (1)
  • chronic lymphocytic leukaemia - allogeneic BMT preferred
  • multiple myeloma - controversial as to whether allogeneic or autologous is the best; standard chemotherapy is rarely curative

Note that BMT is not considered part of standard therapy in the treatment of CLL or multiple myeloma.