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Imipramine is a non sedative tricyclic antidepressant.

The dose is 75 to 225 mg per day in divided doses, with a starting dose of 50 to 75 mg per day, although there may be some problems in the elderly. It is most useful for retarded depression without anxiety.

The dose should be increased gently over 10 days.

The patient should be advised to expect a 10 to 14 day delay before the onset of therapeutic action at each dose level and side effects may make them feel worse before the onset of a therapeutic response.

The summary of product characteristics should be consulted before prescribing this drug.

Last reviewed 01/2018