Medical factors predisposing to infection include:
medical conditions: diabetes, rheumatic or congenital heart disease, asthma or other chronic lung disease, chronic renal or hepatic disease, Down's syndrome and premature or underweight infants
immunocompromised: steroids, immunosuppressants, AIDS, connective tissue disease, cancer or leukaemia, chemotherapy (very dangerous as signs diminished)
previous infection: rheumatic fever, TB or jaundice
surgical conditions: gallstones, diverticular disease, prostatism and prolapse
recent surgery or procedure, dentistry and minor injury
family history or other close contact of infection
medication including self-medication and blood products
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