management of disseminated intravascular coagulation

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The principles of managing disseminated intravascular coagulation include:

  • correction of the underlying condition
  • treatment with blood components
  • pharmacological manipulation of thrombin and plasmin generation

It is generally accepted that any underlying prothrombotic disorder must be corrected as rapidly as possible.

Vitamin K deficiency may cause a coagulopathy similar to DIC, hence 10 mg of vitamin K should be given on twice in 48 hr before a firm diagnosis of DIC is made.

Some centres recommend folate supplements to permit optimal regeneration of platelets.

There is little consensus regarding indications for further interventions.

This should NOT be considered a manual for treatment of this condition, but as a brief summary of the possible treatment options employed. Expert help should be consulted.

Last reviewed 01/2018