types
FREE subscriptions for doctors and students... click here
You have 3 more open access pages.
There are two classic patterns of inheritance:
Autosomal recessive:
- this is the malignant form of osteopetrosis
- abnormalities are present in utero or infancy
- anaemia and neutropenia result from obliteration of the marrow cavities
- extramedullary haematopoiesis results in hepato- splenomegaly
- narrowing of the foramina in the skull may result in hydrocephalus or cranial nerve palsies
Autosomal dominant:
- this is the more benign adult form of osteopetrosis
- anaemia is mild
- neurological involvement is rare
- the main complaint is a predisposition to fractures
Last reviewed 01/2018