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The classical clinical features of acute inflammation according to the ancient Greek scientist Celsus (30 BC to AD 38) were:
To this, Galen (AD 130-200) later added:
Localised acute inflammation is best illustrated by the triple response. Localised inflammation can preciptate systemic signs of acute inflammation; occasionally, a systemic disease e.g. rheumatoid arthritis, can produce localised inflammation.
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