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Fourniere's Gangrene is a soft tissue infection of the perineum and strictly,
the genitalia. Described by Jean-Alfred Fourniere in 1883, It is a localised
form of soft tissue necrotising fasciitis.
Fournier's gangrene is a fulminant necrotizing fasciitis of the external genitalia,
scrotum, or perineal area (1,2)
- men are affected exceedingly more than women, and the majority of patients
suffer from multiple health comorbidities including obesity, diabetes, and
immunodeficiency
- men are more often affected than women, with a ratio of 10:1, and the
disease can affect people of all ages (mean age, 50 years) (3)
- incidence of the disease is estimated at 1.6 men per 100 000. Mortality
rate remains high at 20% to 40% despite improvements in medical care (3)
- clinical findings include fever, pain and swelling, erythema or dark discoloration,
discharge from the wound, induration, and crepitus of the affected area
- key component in accurate diagnosis is imaging with CT being the study of
choice by some (2) - important findings include fascial thickness and subcutaneous
air (2)
- a delay of even a few hours from suspicion of Fournier gangrene to surgical
debridement significantly increases the risk of death (4)
- differential diagnosis of Fournier gangrene includes scrotal and perineal
disorders, as well as intra-abdominal disorders such as cellulitis, abscess,
strangulated hernia, pyoderma gangrenosum, allergic vasculitis, vascular
occlusion syndromes, and warfarin necrosis
- pathogenesis is usually bacterial and the most common organisms identified
include Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Bacteroides
fragilis, Streptococcus species, and Clostridium species
- if Fournier's gangrene is suspected then urgent secondary care management
is indicated - urgently start treatment (including antibiotics and surgical
debridement as required)
- treatment is broad-spectrum antibiotics and adequate surgical debridement
- commonly used antibiotic regimens for Fournier's gangrene include a
second- or third-generation cephalosporin, fluoroquinolones or gentamicin,
and clindamycin; metronidazole may also be included in the regime as coverage
for anaerobic bacteria
- once infection is cleared, later reconstruction of soft tissues may
be required
Reference:
Last edited 03/2019 and last reviewed 10/2020
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