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Tumour suppressor genes and colorectal carcinoma

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Several tumour suppressor genes have been identified as being involved in tumour initiation and progression:

  • inactivation of the DCC gene:
    • DCC stands for Deleted in Colon Cancer
    • on chromosome 18q
    • DCC is a membrane-bound protein that shares sequence homology with neural adhesion molecules (N-CAM)
    • DCC is xpressed in the axons of peripheral and central neurons and in differentiated cells of the intestine
    • DCC mutations have only been found in sporadic colorectal cancers

  • APC:
    • the Adenomatous Polyposis Colon gene
    • mutations of the APC tumour suppressor gene are unique to colorectal carcinomas

  • mutHLS homology genes:
    • these proteins are involved in mismatch repair of DNA
    • dysfunction results in the hereditary non-polyposis colorectal cancer

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