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clopidogrel

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Clopidogrel is an anti-platelet drug, of the thienopyridine class, which is licensed for the secondary prophylaxis of atherosclerotic complications in patients with:

  • ischaemic heart disease
  • cerebrovascular disease
  • peripheral vascular disease

The dose is 75 mg per day.

The principal side-effect is haemorrhage, including:

  • gastrointestinal
  • intracranial

There may be gastrointestinal upset.

Maximal inhibition of platelet aggregation is achieved after 4-7 days with clopidogrel 75 mg per day (1).

The summary of product characteristics should be consulted before prescribing this drug.

Reference:

  1. Solet D et al. The role of adenosine 5'-diphosphate receptor blockade in patients with cardiovascular disease. Am J Med 2001;111:45-53.
  2. Drug and Therapeutics Bulletin 1999; 37 (8): 59-61.
  3. Factfile 12/98. Antithrombotic drugs. British Heart Foundation.

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