prothrombin G20210A

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Prothrombin G20210A is due to a single base change in the 3' untranslated region of the prothrombin gene and is associated with an elevated plasma level of prothrombin.

  • there is a 3x increased risk of thrombosis associated with this condition
  • the prevalence in patients with venous thromboembolism is about 6%
  • prevalence in the normal population is about 2%

There is increasing evidence that individuals with two or more laboratory characterisable thrombophilic abnormalities (or who are homozygous for either factor V Leiden or prothrombin G20210A) are at a greater risk of thrombosis than those in whom there is a single gene abnormality (1)


(1) British Heart Foundation (Factfile 2/2002). Thrombophilia

Last reviewed 01/2018