statin and fibrate combination therapy

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  • for most people with both elevated cholesterol and triglycerides, treatment should still commence with a statin
  • if persistent hypertriglyceridaemia is present after LDL targets are achieved, a combination of a statin with a fibrate (using fenofibrate, bezafibrate, or ciprofibrate) can be considered on specialist advice


  • gemfibrozil should not be used in combination with a statin
  • if a statin–fibrate combination is used, then monitoring of CK and ALT is appropriate


  1. JBS2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice. Heart 2005; 91 (Supp 5).

Last reviewed 04/2018