antidepressant onset of action
Last reviewed 01/2018
- data using weekly or daily rating demonstrate that maximum improvement
with antidepressant treatment occurs during the first 2 weeks, with some improvements
within the first 3 days (1)
- implication for clinical practice is that current evidence suggests it would be more accurate to say to patients that in 90% of cases substantial improvement occurs within the first 2 weeks, but that benefit continues to build up over several weeks
- Mitchell AJ. Two-week delay in onset of action of antidepressants: new evidence. The British Journal of Psychiatry (2006) 188: 105-106.
- Warwick Medical School (August 2007).Clinical Pharmacology Newsletter.