Up to 15% of babies pass meconium during delivery, which is dangerous if aspirated. Unfortunately, birth asphyxia provokes vigorous breathing movements in the foetus which contributes to aspiration of meconium into the respiratory tree.
Meconium may act as a ball valve - allowing air in but not out. This results in a radiographic appearance of patchy consolidation interspersed with areas of overinflation.
Meconium is also acidic and acts as an irritant, resulting in a chemical pnemonitis. Bacteria may cause superinfection.
Meconium passage in a preterm infant is always abnormal, and should raise suspicion of Listeria infection.
NICE guidance states (1):
Presence of meconium in labour
Reference:
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