Last reviewed 01/2018
- autoantibodies to these proteins are found in SLE, especially in drug-induced
- characteristic pattersn of antibodies to different histone proteins can be elicited by certain drugs e.g. procainamide
- anti-histone antibodies
are found in about 95% of cases of drug-induced SLE in the absence of other autoantibodies
- also found in about 50% of idiopathic lupus and far less frequently in systemic sclerosis, rheumatoid arthritis and mixed connective tissue disorders
- (1) Sherley-Dale A. Serum autoantibodies and connective tissue disorders. Dermatology in Practice (April 2008); 16(1).