there is evidence that ezetimibe 5mg (split 10mg tablet) has similar efficacy to ezetimibe 10mg and greater tolerability (1,2)
in a study of 272 patients, 197 had evaluable baseline and posttreatment LDL-C (55 taking the 5-mg dose and 142 taking the 10-mg dose)
the effects of ezetimibe 5 and 10 mg on all lipid parameters were similar. Ezetimibe 10 mg reduced LDL-C by 26.1%, whereas 5 mg reduced LDL-C by 25.8% (1)
Reference:
1) Baruch L et al. Ezetimibe 5 and 10 mg for lowering LDL-C: potential billion-dollar savings with improved tolerability, Am J Manag Care 2008;14:637-641
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