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Norovirus gastroenteritis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Acute gastroenteritis is a common ailment in humans and remains a major public health concern worldwide. Norovirus, a member of the genus Norovirus, in the family Caliciviridae, is considered to be a common cause of outbreaks and sporadic cases of acute gastroenteritis among all age groups.

Reservoir:

  • gastrointestinal tract of humans
  • capable of surviving in the environment

Epidemiology:

  • commonest cause of gastroenteritis in England and Wales
  • increased prevalence during colder months
  • persons of all ages are at risk from infection. The elderly and very young are at greater risk of developing dehydration
  • most people with Norovirus do not access health care services. Outbreaks are very common in semi-closed environments such as schools, hospitals and nursing homes.

Transmission occurs by ingestion of contaminated food or water, exposure to contaminants (fomites, aerosolized vomitus), and person-to-person contact.

  • known to have high transmissibility and a low infectious dose, Norovirus has been recognized as the primary source of outbreaks in a range of environments, including nursing homes, hospitals, schools, hotels, and cruise ships

Incubation period:

  • usually 12-62 hours, rarely 6-84 hours

Noroviruses can be divided into five genogroups based on the genome sequence of the RNA-dependent RNA polymerase and the capsid regions

  • of the five identified genogroups, three distinct strains (GI, GII, and GIV) have been associated with human gastroenteritis,

Clinical features:

  • symptoms of a norovirus usually start between 24-48 hours after the initial infection, although they can start after as little as 12 hours. The first symptom is usually a sudden onset of nausea, which is followed by projectile vomiting and watery diarrhoea
  • some people may also have:
    • a mild fever
    • headaches
    • abdominal cramps, or
    • myalgia
  • in rare cases of the norovirus, seizures can occur
  • symptoms normally last between 12-60 hours, although most people make a full recovery within one to two days. However, the diarrhoea may last slightly longer

Infectivity:

  • whilst symptomatic and for 48-72 hours after diarrhoea has stopped.

Management:

  • no specific treatment
  • ensure adequate fluid intake; paracetamol if fever or headaches

Notes:

  • the ease of person-to-person transmission, low infectious dose and ability to survive in the environment for several days all contribute to the high number of outbreaks caused by Norovirus
  • immunity is short-lived; infection with one strain of Norovirus is not protective against other strains.

Reference:


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