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Maddrey's discriminant function (DF)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

NICE suggest the use Maddrey's discriminant function (DF) to determine treatment in people with severe acute alcohol related hepatitis (1)

  • Maddrey's discriminant function (DF) was described to predict prognosis in alcohol-related hepatitis and identify patients suitable for treatment with steroids
    • it is 4.6 x [prothrombin time - control time (seconds)] + bilirubin in mg/dl.
      • to calculate the DF using bilirubin in micromol/l divide bilirubin value by 17
  • DF of 32 or more
    • consider liver biopsy to confirm diagnosis
    • offer corticosteroid treatment

Reference:

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