pathogenesis of optic nerve damage in glaucoma
Last reviewed 06/2022
The pathogenesis of optic nerve damage in glaucoma remains uncertain but two mechanisms which are thought to be responsible have been proposed (1,2)
- mechanical theory - increased intra ocular pressure (IOP) results in posterior displacement of the lamina cribrosa causing damage to the retinal ganglion cells that pass through it
- vascular theory - axonal death results from poor optic nerve head capillary perfusion. IOP is normal (2)
Much doubt exists regarding these two mechanisms and evidence suggests that glaucomatous changes may result from a complex interaction between these two (2).