diagnostic criteria for MGUS (Monoclonal Gammopathy of Unknown Significance), asymptomatic myeloma and symptomatic myeloma

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The diagnosis of myeloma should be made using the criteria proposed by the International Myeloma Working Group (IMWG). These criteria distinguish between myeloma and MGUS principally on the basis of M protein concentration, percentage of bone marrow plasma cells and the presence or absence of myeloma related organ and tissue impairment (1).

  • MGUS
    • M-protein in serum <30 g/l
    • Bone marrow clonal plasma cells <10 % and low level of plasma cell infiltration in a trephine biopsy (if done)
    • No related organ or tissue impairment ((no end organ damage including bone lesions)

  • Asymptomatic myeloma
    • M-protein in serum >30 g/l and/or Bone marrow clonal plasma cells >10 %
    • No related organ or tissue impairment (no end organ damage including bone lesions) or symptoms

  • Symptomatic myeloma
    • M-protein in serum and/or urine
    • Bone marrow (clonal) plasma cells or biopsy proven plasmacytoma
    • Myeloma-related organ or tissue impairment (including bone lesions)

Reference:

Last reviewed 08/2021