ACE inhibitors and hyponatraemia

Last reviewed 01/2018

  • angiotensin converting enzyme (ACE) inhibitors have been associated with dilutional hyponatremia (1,2,3):

    • ACE inhibitors alone can precipitate hyponatremia without co-administration of thiazide diuretics

    • hyponatremia induced by ACE inhibitors appears to be dilutional and is accompanied by features of SIADH

    • discontinuing the ACE inhibitor leads to resolution of the hyponatremia.