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Clinical comparison between features of gynaecomastia and breast cancer

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

differences between a malignancy and gynaecomastia:

The first step in clinical evaluation of patients consists of differentiating gynecomastia from other causes of enlarged breast tissue or mass (1).
Physical examination in male breast enlargement: (1,2)


Gynaecomastia

Malignancy

Bilateral (usually) or unilateral

Unilateral (usually) or bilateral (rarely)

Painless or painful (occasionally)

Painless or painful (uncommon)

Central (subareolar)

Central (70-90%) or eccentric*

Smooth

Irregular*

Firm

Rubbery or hard*

Mobile

Fixed*

Normal nipple

Nipple deformity (17-30%) or discharge (<10%)*

Normal skin

Thickened, red, or ulcerated skin*

Normal axilla

Axillary adenopathy**

*mandates surgical evaluation.
**may be associated with locally advanced malignancy
Reference:


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