U3 - RNP autoantibody

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U3-RNP autoantibody

  • target antigen - Fibrillarin
  • occurs in 5% systemic sclerosis
  • clinical association
    • isolated pulmonary arterial hypertension
    • cardiac involvement
    • myositis and poor outcome in diffuse cutaneous systemic sclerosis

Reference:

  • 1) Arthritis Research Campaign (2010). Topical Reviews - Systemic sclerosis and related disorders.

Last reviewed 01/2018

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