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- cough associated with statin use
- study evidence shows that cough may be associated with statin use (1).
An 8 week tolerability study for two different formulations for atorvastatin
revealed cough as an adverse reaction in about 5% of patients taking a
statin in this particular study (1)
- if simply cough associated with statin use (no evidence of interstitial
lung disease) then this will resolve with withdrawal of the statin treatment
- statin induced lung injury
- more significantly than cough without pulmonary lesions present on imaging
- there is evidence that statin use has been associated with lung injury
( interstitial lung disease)
- statins have been rarely associated as a cause of interstitial lung
disease (ILD)
- shows that statin-induced ILD is a newly recognized side effect
of statin therapy which can present as a cough. Unfortunately, little
is known about the mechanism of lung injury
- Fernandez and colleagues reported that interstitial lung disease
(ILD), comprising a group of disorders with similar pathological findings
including cellular infiltration, scarring and/or architectural disruption
of the pulmonary parenchyma involving alveolar lining cells, small
and large airways, endothelial basement membranes and occasionally
the pleura, was found in 0.01-0.4% of patients who had statin-induced
adverse events
- a diagnosis of statin induced lung injury
- the following criteria for presumed drug-induced lung injury
caused by statins has been suggested (3):
- (1) treatment with statins;
- (2) newly developed pulmonary lesions presenting as ILD
on the imaging studies after statin treatment;
- (3) other causes of lung diseases extensively excluded clinically;
- (4) obvious clinical and radiological improvement after
discontinuation of statins
- the contribution of steroid therapy in the treatment of statin-induced
ILD is uncertain, but based on anecdotal experience, steroid therapy
should be attempted when statin withdrawal fails to improve symptoms
(2)
- ILD has been reported with most statins, suggesting that statin-induced
ILD is a class effect and not a specific statin effect (2)
Reference:
Last reviewed 01/2018
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