people with a high risk of inherited pancreatic cancer
NICE suggest for people with inherited high risk of pancreatic cancer (1)
- ask people with pancreatic cancer if any of their first-degree relatives
has had it
- surveillance should be offered for pancreatic cancer to people with:
- hereditary pancreatitis and a PRSS1 mutation
- BRCA1, BRCA2, PALB2 or CDKN2A (p16) mutations, and one or more first-degree relatives with pancreatic cancer
- Peutz–Jeghers syndrome
- surveillance for pancreatic cancer should be considered for people with:
- 2 or more first-degree relatives with pancreatic cancer, across 2 or more generations
- Lynch syndrome (mismatch repair gene [MLH1, MSH2, MSH6 or PMS2] mutations)
and any first-degree relatives with pancreatic cancer
- an MRI/MRCP or EUS should be considered for pancreatic cancer surveillance in people without hereditary pancreatitis.
- a pancreatic protocol CT scan should be considered for pancreatic cancer surveillance in people with hereditary pancreatitis and a PRSS1 mutation.
- do not offer EUS to detect pancreatic cancer in people with hereditary pancreatitis
Last edited 04/2018 and last reviewed 09/2019