people with a high risk of inherited pancreatic cancer

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NICE suggest for people with inherited high risk of pancreatic cancer (1)

  • ask people with pancreatic cancer if any of their first-degree relatives has had it

  • surveillance should be offered for pancreatic cancer to people with:
    • hereditary pancreatitis and a PRSS1 mutation
    • BRCA1, BRCA2, PALB2 or CDKN2A (p16) mutations, and one or more first-degree relatives with pancreatic cancer
    • Peutz–Jeghers syndrome

  • surveillance for pancreatic cancer should be considered for people with:
    • 2 or more first-degree relatives with pancreatic cancer, across 2 or more generations
    • Lynch syndrome (mismatch repair gene [MLH1, MSH2, MSH6 or PMS2] mutations) and any first-degree relatives with pancreatic cancer

  • an MRI/MRCP or EUS should be considered for pancreatic cancer surveillance in people without hereditary pancreatitis.
  • a pancreatic protocol CT scan should be considered for pancreatic cancer surveillance in people with hereditary pancreatitis and a PRSS1 mutation.
  • do not offer EUS to detect pancreatic cancer in people with hereditary pancreatitis

Reference:

Last edited 04/2018 and last reviewed 09/2019

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