zinc and COVID-19 (COVID)

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Zinc is an essential metal being involved in a variety of biological processes due to its function as a cofactor, signaling molecule, and structural element (1)

  • is involved in the regulation of carbohydrate and lipid metabolism, as well as the functioning of the reproductive, cardiovascular, and nervous system
  • regulates proliferation, differentiation, maturation, and functioning of leukocytes and lymphocytes
  • plays a signaling role involved in the modulation of inflammatory responses
  • also a component of nutritional immunity (2)
    • alteration of zinc status significantly affects immune response resulting in increased susceptibility to inflammatory and infectious diseases including acquired immune deficiency syndrome, measles, malaria, tuberculosis, and pneumonia (1)
    • data demonstrate that zinc status is associated with the prevalence of respiratory tract infections in children and adults (2)
    • also thought that zinc has the potential to support COVID-19 therapy due to its immunomodulatory roles and direct antiviral effects (2)
      • study evidence showed that infected patients had significantly lower zinc concentrations than potentially non-infected participants (2)

In adult populations unlikely to be zinc deficient, there was some evidence suggesting zinc might prevent RTIs (respiratory tract infections) symptoms and shorten duration (3)


Last edited 11/2021 and last reviewed 11/2021