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Dutasteride in androgenic alopecia (AGA)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Dutasteride in androgenic alopecia:

  • dutasteride is a dual 5alpha-reductase
    • has been used for the treatment of male androgenetic alopecia
      • evidence shows that dutasteride seems to provide a better efficacy compared with finasteride in treating an drogenetic alopecia. The two drugs appear to show similar rates of adverse reactions, especially in sexual dysfunction (1)

      • a prospective study investigating sexual dysfunction associated with dusteride use for androgenic alopecia in men found (2):
        • incidence of sexual adverse events was approximately twofold higher in the dutasteride group (16%) than the placebo group (8%) during the double-blind period; the overall incidence of sexual adverse events was lower (5%) during the open-label period
        • all adverse events were mild to moderate in severity and considered treatment-related
        • adverse events resolved while on study treatment or after the end of treatment and did not lead to treatment discontinuation.

  • comparing treatments for male androgenic alopecia
    • analysis of 23 trials indicate 5mg/d oral dutasteride has highest probability of being most efficacious treatment, followed by (in decreasing order of efficacy): 5mg/d oral finasteride (OF), 5mg/d oral minoxidil (OM), 1mg/d OF, 5% topical minoxidil (TM), 2% TM, & 0.25mg/d OM (3)

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