alternative options for women taking sequential HRT preparations with transdermal oestradiol

Last edited 04/2022 and last reviewed 04/2022

Women taking sequential HRT preparations with transdermal oestradiol can consider the following options below:

  • Evorel Sequi patches
    • provides transdermal oestradiol with sequential progestogen (norethisterone)
    • alternatively, women can consider transdermal oestrogen delivery with an alternative progestogen by taking oestrogen and progestogen separately:
      • Oestrogen:
        • Evorel 50 patches
        • Estradot 50 patches
        • Estraderm 50 patches
        • Femseven mono 50 patches
        • Progynova TS 50 patches
      • Or an oestradiol gel preparation such as Oestrogel or Sandrena:
        • Oestrogel one measure twice a day would be equivalent to the oestrogen dose in Evorel Sequi
        • Or Sandrena 1mg sachet a day would be equivalent to the oestrogen dose in Evorel Sequi
        • Or oestradiol spray Lenzetto three sprays (40 mcgm) would be equivalent to the oestrogen dose in Evorel Sequi

      • Progestogen:
        • Micronised Progesterone: Utrogestan 200mg orally for 12 days a month at night (cyclical)
        • Or Provera 10mg orally for 12 days a month
        • Or Norethisterone 5mg orally for 12 days a month
        • Or Mirena IUS

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