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Nintedanib for treating idiopathic pulmonary fibrosis when forced vital capacity is above 80% predicted

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Nintedanib is recommended as an option for treating idiopathic pulmonary fibrosis in adults, only if:

  • they have a forced vital capacity of above 80% predicted
  • the company provides it according to the commercial arrangement

Notes:

  • NICE note that "..the technology appraisal is for treating idiopathic pulmonary fibrosis in people with a forced vital capacity (FVC) above 80% predicted. Nintedanib is also recommended for people with an FVC between 50% and 80% predicted..Currently, the only option for people with idiopathic pulmonary fibrosis with an FVC above 80% predicted is best supportive care.."
  • Nintedanib is a tyrosine kinase inhibitor which displays anti-angiogenesis properties through blockade of the vascular endothelial growth factor (VEGF) pathway
  • been shown to significantly reduce the progression of idiopathic pulmonary fibrosis (2)
    • gastrointestinal events, mainly diarrhoea, are the main adverse events caused by the treatment
    • studies suggest that nintedanib stabilizes lung function till lung transplantation, with no increased surgical complications or postoperative mortality after lung transplantation

Reference:

  1. NICE (February 2023). Nintedanib for treating idiopathic pulmonary fibrosis when forced vital capacity is above 80% predicted
  2. Rivera-Ortega P, Hayton C, Blaikley J, Leonard C, Chaudhuri N. Nintedanib in the management of idiopathic pulmonary fibrosis: clinical trial evidence and real-world experience. Ther Adv Respir Dis. 2018 Jan-Dec;12:1753466618800618

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