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Switching antidepressant (vortioxetine to selective serotonin reuptake inhibitors (SSRIs)) in adults

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Vortioxetine to selective serotonin reuptake inhibitors (SSRIs)

  • is limited experience with this switch so extra caution is required to avoid serotonin syndrome.

Direct switch

  • a direct switch, i.e. stopping one antidepressant and then starting the new antidepressant the following day, is normally possible

Stop, washout and switch

  • alternatively, stop vortioxetine; wait for a period before starting the SSRI. Clinicians should decide the duration of the washout period on a case-by-case basis.

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