Demeclocycline
Demeclocycline is a tetracyline drug used in the treatment of hyponatraemia caused by syndrome of inappropriate ADH secretion, where fluid restriction has not been effective.
It may act to directly block the action of ADH on the tubule; in doing so it effectively causes a nephrogenic diabetes insipidus.
Side effects include diabetes insipidus and a photosensitive rash.
Demeclocycline can cause reversible azotaemia and sometimes nephrotoxicity, especially in patients with cirrhosis.
The efficacy of demeclocycline is variable, and can depend on the underlying aetiology.
Reference:
- Wilke RA; Potential Use of Pharmacogenetics to Reduce Drug-Induced Syndrome of Inappropriate Antidiuretic Hormone (SIADH). J Pers Med. 2021 Aug 28;11(9).
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