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Depo Provera and enzyme-inducing drugs

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

NICE state that (1):

  • the use of additional barrier methods should be discussed with women and girls taking enzyme-inducing anti-epileptic drugs (AEDs) and oral contraception or having depot injections of progestogen

However FSRH guidance states with respect to depot medroxyprogesterone acetate (DMPA) or the levonorgestrel-releasing intrauterine system; used concurrently with enzyme-inducing AEDs

  • no interaction and no need for extra precautions


  1. NICE (April 2018).The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care.
  2. Faculty of Sexual & Reproductive Healthcare Clinical Guidance.Clinical Guidance: Drug Interactions with Hormonal Contraception January 2018.

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