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Enzyme-inducers and implantable contraceptives

Authoring team

If a woman is using enzyme-inducing drugs e.g. phenytoin then this is a contraindication for the use of implants (1).

NICE state that the progesterone-only pill is not recommended as reliable contraception in women taking enzyme-inducing anti-epileptic drugs

  • the progestogen-only pill is not recommended as reliable contraception in women and girls taking enzyme-inducing AEDs

  • the progestogen implant is not recommended in women and girls taking enzyme-inducing AEDs

Reference:

  1. Prescriber (2001), 12 (5), 83-95.
  2. NICE (April 2018).The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care.

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