This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Depo Provera and enzyme-inducing drugs

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

NICE state that (1):

  • the use of additional barrier methods should be discussed with women and girls taking enzyme-inducing anti-epileptic drugs (AEDs) and oral contraception or having depot injections of progestogen

However FSRH guidance states with respect to depot medroxyprogesterone acetate (DMPA) or the levonorgestrel-releasing intrauterine system; used concurrently with enzyme-inducing AEDs

  • no interaction and no need for extra precautions


  1. NICE (April 2018).The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care.
  2. Faculty of Sexual & Reproductive Healthcare Clinical Guidance.Clinical Guidance: Drug Interactions with Hormonal Contraception January 2018.

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page