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Clinical features

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

There is a gradually progressive spastic weakness of the legs with increasing difficulties with walking.

The tendon reflexes are brisk in the legs with extensor plantar responses.

If onset is during childhood then pes cavus is common.

More extensive disease may affect the arms and the sphincters.

Complicated hereditary spastic paraplegia is associated with:

  • cerebellar ataxia and dysarthria
  • optic atrophy and pigmentary macular degeneration
  • sensorimotor polyneuropathy
  • epilepsy
  • ichthyosis
  • dementia

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