Acute phase reaction
The acute phase reaction describes the global systemic physiological response to acute insults such as inflammation by:
- fever
- chills
- lethargy
- increased catabolism of protein
- increase in slow wave sleep
- decreased appetite
- hypotension
- neutrophilia
- increase in acute phase proteins
The likely instigators of all of these effects are cytokines, most likely IL-1 and TNF. They are released by peripheral monocytes in direct relation to the level of inflammation, hypothetically to increase the level of acute phase proteins necessary for their activity.
Reference
- Germolec DR, Shipkowski KA, Frawley RP, Evans E. Markers of Inflammation. Methods Mol Biol. 2018;1803:57-79
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