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Clinical effects

Authoring team

The most important effects of histamine are on:

  • the cardiovascular system in some type I hypersensitivity reactions
  • gastric secretion; increased, and H2 receptors are the target for effective antagonist drugs
  • during inflammation: histamine is thought to be a key mediator involved in the early stages of acute inflammation; antihistamines have minimal effect in averting vasodilatory inflammatory responses once histamine has been depleted.

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