normochromic normocytic anaemia of moderate degree and sickle cells present
target cells and sickle cells on the blood film
the reticulocyte count is usually elevated to 10-20%
the use of laboratory investigations and confirmatory investigations depends on the mode of presentation and on available facilities, common methods used in the diagnosis include:
full blood count, blood film, reticulocyte count
sickle solubility test (e.g. – sickledex)
high performance liquid chromatography (HPLC)
isoelectric focusing (IEF)
cellulose acetate electrophoresis (CAE) (1)
prenatal diagnosis:
amniocentesis and chorionic villus sampling are employed
extracted DNA may be characterised by restriction fragment polymorphism analysis or Southern blotting with a mutation-specific oligonucleotide
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