Aetiology
Examples of extravascular haemolysis include:
- sickle cell disease:
- during a crisis, hypoxia results in gelling of the HbS
- the red cell become less deformable
- phagocytosis within mononuclear cells in the spleen results in extravascular haemolysis
- hereditary spherocytosis:
- the abnormal cytoskeleton reduces the deformability of the red cells
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