Tumour growth and chemotherapy
Tumour growth can be described in terms of the multiple of functions of:
- the cell cycle time, T
- the growth fraction, G
- the rate of cell loss, L i.e.: fT x fG x fL = tumour doubling time
G is proportional to tumour mass, such that larger tumours have a smaller growth fraction - Gompertzian growth. Thus small tumours grow faster
From this, problems with chemotherapy in solid tumours are as follows:
- low growth fraction
- poor drug penetration
- intrinsic drug resisitance
- develepment of drug resistance
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