This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages without signing in

Genetic factors

Authoring team

Genetic factors are important in the aetiology of type 2 diabetes mellitus:

  • concordance rate for type 2 diabetes (NIDDM) in monozygotic twins is about 90% - much higher than for IDDM
  • for siblings of patients with type 2 diabetes (NIDDM) the lifetime risk of developing the condition is approximately 40%
  • there are no significant HLA associations

Susceptibilty genes identified include:

  • calpain-10 on chromosome 2

Specific single gene mutations have been identified for rare familial forms of non-insulin dependent diabetes mellitus. The proportion of type 2 diabetes (NIDDM) patients with any of these mutations is between 1% & 5% (1).

Latent autoimmune diabetes of adults (LADA) is classified as a form of type 2 diabetes (1).

Reference:

  • 1) Nature Genetics (2000), 26, 163-75.

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.