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Risk categories for selected prognostic factors

Authoring team

With the identification and validation of new prognostic factors, patients can be categorised into high, intermediate and low risk for disease progression (1).

  • high risk
    • del (17p)/TP53 gene mutation
    • del (11q)
    • IgHV unmutated
    • CD38 positive
    • ZAP-70 positive
    • lymphocyte doubling time < 6 months
    • b2-microglobulin > 3.5 mg/L

  • intermediate
    • trisomy 12

  • low
    • del(13q)
    • normal cytogenetics
    • mutated IgHV (1)

Reference:

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