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Laboratory features

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Micrangiopathic haemolytic anaemia is characterised by:

  • fragmented red blood cells - schistocytes, helmet cells, triangle forms - in peripheral blood smear
  • normocytic, normochromic
  • Hb usually < 10 gm/dl
  • marked reticulocytosis; occasionally, nucleated RBC's
  • haemolysis - increased serum indirect bilirubin, LDH, and serum haemoglobin; absent haptoglobin
  • negative Coomb's test

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