Incident cardiovascular events/cardiovascular disease (CVD) and past history of cancer

Incident cardiovascular events and past history of cancer

• analysis of 18,714 pts with history of 6 common cancers (CAs:breast,lung,prostate,colorectal,uterus,haematological) & equal number of non-CA matched comparators found link between CA history & increased risk of wide range of incident CVD (cardiovascular disease) & mortality outcomes over 12 yrs follow-up
  • is evidence cancer confers an increased risk to a wide range of cardiovascular events, which is independent of traditional cardiovascular risk factors and extends for a prolonged time after a cancer diagnosis
  • participants with cancer had high burden of vascular risk factors and prevalent CVDs
    • haematological cancer was associated with increased risk of all incident CVDs considered , larger chamber volumes, lower ejection fractions, and poorer LV strain
    • breast cancer was associated with increased risk of selected CVDs (non-ischaemic cardiomyopathy (NICM), HF (heart failure), pericarditis and VTE (venous thromboembolism)), HF/NICM death, hypertensive disease death, lower LV ejection fraction, and lower LV global function index
    • lung cancer was associated with increased risk of pericarditis, HF, and CVD death
    • prostate cancer was linked to increased VTE risk.

Reference:

• Raisi-Estabragh Z, Cooper J, McCracken C, et al. Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer. Heart Published Online First: 18 April 2023. doi: 10.1136/heartjnl-2022-321888