Isocitrate dehydrogenase is actually 2 slightly different mitochondrial enzymes which convert 6 carbon isocitrate into 5 carbon 2-oxoglutarate during the tricarboxylic acid cycle. One enzyme reduces NAD during the reaction, the other reduces NADPH.
Also, 1 molecule of carbon dioxide is produced during the reaction.
The molecule of NAD(P)H can produce 3 molecules of ATP via the electron transport chain.
Isocitrate dehydrogenase is one target for TCA cycle modulation.
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